Ex vivo tests of actives

Human skin

• Fullthickness skin (epidermis, dermis, hypodermis)
• Dermatomed skin
• Stratum cornuem

Type of tests

• Penetration / diffusion tests on Franz cells: kinetics of actives diffusion, distribution and visual display of actives in the skin layers
• Skin structure analysis
  

Equipments

• Scanning electron microscope
• Transmission electron microscope
• Confocal microscope
• Ultrasound scan
• Histology

Human nails

• Dorsal layer
• Intermediate layer
• Whole nail + nail bed

Type of tests

• Trans-ungual  permeation  model using Franz diffusion cells : kinetics of actives diffusion, distribution and visual display of actives in the nail
• Characterization of nail layers: hardness, wetability, roughness
• Nail structure analysis
  

Equipments

• Scanning electron microscope
• Confocal microscope
• Histology

Type of tests

• Penetration / diffusion tests on actives: visual display of actives in hair by confocal microscope
• Characterization of hair: colorimetry measurement, mechanical tests (breaking, flexibility…)
• Hair structure analysis
  

Equipments

• Scanning electron microscope
• Confocal microscope
• Histology